2240 BCE: Naram-Sin of Akkad campaigns against the Amorites in northern Syria.
2034 BCE: Amorites migrate into Mesopotamia, possibly from Syria or Arabia.
1274 BCE: Battle of Kadesh between Pharaoh Ramesses II of Egypt and King Muwatalli II of the Hittites.
332 BCE: Alexander the Great conquers Syria and turns toward Egypt.
274 BCE - 271 BCE: The first Syrian war, marking the beginning of the contest between the Ptolemies and the Seleucids for Phoenicia and Coele-Syria.
195 BCE: After the battle at Panion, the Seleucids finally take the rule of Phoenicia from the Ptolemies. Tyre and the other Phoenician cities will remain in the Seleucid power until the Roman conquest of Syria.
64 BCE: The Roman general Pompey defeats the Seleucid Antiochus XIII and incorporates Syria as a province of the Roman empire.
117 CE: Death of Trajan. Now governor of Syria, Hadrian becomes emperor as he was previously adopted by Trajan.
128 CE - 134 CE: Hadrian travels to Greece, Anatolia, Syria, Judea, Arabia, Egypt and goes back via Greece.
262 CE - 266 CE: Odaenathus expels Persian garrisons and restores Syria and Armenia to the Roman Empire. Odaenathus invades Mesopotamia, and inflicts two defeats upon Shapur I, which ends with the sack of Ctesiphon.
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