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10000 BCE: Beginnings of agriculture in the Middle East.
9000 BCE: Cultivation of wild cereals in the Fertile Crescent.
8000 BCE: End of the last Ice Age.
6500 BCE: First pottery in the Near East.
6000 BCE: Nineveh is first settled.
5400 BCE: The City of Eridu is founded.
5000 BCE: Founding of Uruk.
5000 BCE: Irrigation and agriculture begin in earnest in Mesopotamia.
4300 BCE - 3100 BCE: Uruk period in Mesopotamia. First cities.
4000 BCE: First settlement of Ur.
3400 BCE: Priests become the rulers of Mesopotamian cities.
3000 BCE: Sumer civilization in Mesopotamia use gold in jewellery manufacture.
2400 BCE: First use of war chariots in Mesopotamia.
2350 BCE: First code of laws by Urukagina, king of Lagash.
2334 BCE - 2279 BCE: Sargon of Akkad (the Great) reigns over Mesopotamia and thus creates the world's first empire.
2330 BCE: Sargon of Akkad sacks Ur.
2150 BCE - 2000 BCE: The Sumerian Epic of Gilgamesh written on clay tablets.
2116 BCE - 2110 BCE: Utchengal's reign over Sumerian and Akkadian cities.
2112 BCE - 1950 BCE: Third dynasty of Ur.
2111 BCE - 2094 BCE: Ur-Nammu's reign, according to middle chronology.
2100 BCE: The Code of Ur-Nammu (the earliest known code of laws) is written.
2100 BCE: First ziggurats in Ur, Eridu, Uruk, and Nippur.
2083 BCE - 2050 BCE: The Dark Age of Mesopotamia.
2034 BCE: Amorites migrate into Mesopotamia, possibly from Syria or Arabia.
2000 BCE - 1600 BCE: Amorite period in Mesopotamia.
2000 BCE: Domesticated horses introduced in Mesopotamia.
1950 BCE: Elam conquers Ur.
1900 BCE: Ashur, capial of Assyria, is founded.
1900 BCE: The first aqueducts were constructed in Mesopotamia and on Minoan Crete
1900 BCE - 1400 BCE: Trade flourishes between Mesopotamia and other regions.
1894 BCE: Amorite dynasty established in Babylon.
1795 BCE - 1750 BCE: Life of Hammurabi, king of Babylon.
1787 BCE: Hammurabi of Babylon conquers Uruk and Isin.
1760 BCE: The Code of Hammurabi: One of the earliest codes of law in the world.
1757 BCE: Hammurabi of Babylon destroys Mari.
1680 BCE: Hurrians occupy Assyria.
1595 BCE: King Mursilis of the Hittites sacks Babylon. Begin of Babylonian "dark ages."
1595 BCE: Hittites sack Babylon, ending Amorite rule.
1550 BCE: Kingdom of Mittani is founded.
1500 BCE: Rise of the kingdom of Mitanni.
1500 BCE: Egyptian empire extends to the Euphrates.
1472 BCE: Mittani annexes Assyria.
1400 BCE: Assyria regains its independence.
1350 BCE: Peak of Mitanni power, it is considered a great nation.
1350 BCE - 1250 BCE: The Hittite empire is at its peak.
1344 BCE - 1322 BCE: King Suppiluliumas I of the Hittites sacks the Mitanni capital Washukanni and installs Shattiwaza as vassal king.
1328 BCE: Western Mittani is conquered by the Hittites.
1285 BCE: Peak of Hittite power.
1220 BCE: Babylon is under Assyrian control.
1080 BCE: Aramaeans invade Mesopotamia.
1000 BCE: Chaldeans occupy Ur.
853 BCE: Babylonian kings depend on Assyrian military support.
750 BCE - 705 BCE: Peak of the Assyrian empire.
734 BCE: Babylon is captured by Chaldeans.
729 BCE: Babylon is occupied by Assyrians.
612 BCE: Downfall of the Assyrian empire.
605 BCE - 562 BCE: Nebuchadnezzar II is king of Babylon.
539 BCE: Fall of Babylon, conquered by Cyrus of Persia. Return of the Jews.
500 BCE - 330 BCE: The Achaemenid Empire rules in Mesopotamia, Persian Royal Road in use.
485 BCE: Babylon is destroyed by Xerxes, King of Persia.
323 BCE - 31 BCE: The Hellenistic Age.Greek thought and culture infuses with indigenous people.
312 BCE: Seleucos conquers Babylon and founds the Seleucid dynasty.
304 BCE - 64 BCE: Rule of the Seleucids in Mesopotamia.
129 BCE: Parthians conquer Mesopotamia. The Silk Road to China is now controlled by the Parthians.
100 BCE: Ctesiphon becomes Parthian capital.
115 CE - 117 CE: Rome occupies Mesopotamia.
224 CE: Sasanians overthrow the Parthians.
234 CE: Emperor Maximinus Thrax is governor of Mesopotamia.
262 CE - 266 CE: Odaenathus expels Persian garrisons and restores Syria and Armenia to the Roman Empire. Odaenathus invades Mesopotamia, and inflicts two defeats upon Shapur I, which ends with the sack of Ctesiphon.
637 CE: Muslim Conquest of Mesopotamia.